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KMID : 1100220090080020088
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Dementia and Neurocognitive Disorders
2009 Volume.8 No. 2 p.88 ~ p.97
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Integrity of the Subcortical Structures in Cognitively Normal Diabetics
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Kim Hee-Jin
Moon Yeon-Sil
Han Seol-Heui
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Abstract
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Background: It has been well known that serum glucose level is associated with cognitive dysfunction. People with type II diabetes have more hippocampal and amygdalar atrophy than non- diabetes. Besides brain atrophy, it is postulated that type II diabetes might affect the white matter structures. This leads to executive dysfunctions, which is important for every day function.
Purpose: The purpose of investigation was to assess the degree of subcortical white matter disruption both at structural and functional levels in diabetics without any subjective cognitive complaints.
Methods: 21 patients with type II diabetes (mean age 65.0± 6.6 years, mean duration 4.0 ± 2.6 years) and 21 healthy control subjects without any subjective cognitive complaints (mean age 65.0±6.8) participated in this study. We employed diffusion tensor imaging analysis for the assessment of structural integrity of subcortical white matter. We adopted the Executive Interview (EXIT 25) to assess executive functional status.
Results: Diabetics showed a tendency to have higher EXIT25 score compared to control group. However, white matter disruption was observed in the areas of left frontal, left deep temporal and bilateral occipital subcortices in diabetics (each Fractional Anisotrophy; FA value, 0.37±0.07, 0.39±0.06, 0.38±0.05, 0.34±0.08).
Conslusion: These results showed diabetes affected the integrity of white matter in the area of anterior part of the brain, and this might associated with dysfunction of frontal executive function.
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KEYWORD
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Diabetes mellitus, EXIT25, white matter, diffusion tensor image
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